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. Author manuscript; available in PMC: 2017 May 1.
Published in final edited form as: J Hepatol. 2016 Jan 19;64(5):1137–1146. doi: 10.1016/j.jhep.2016.01.010

Figure 6. Expression of markers in biliary fibrosis induced by BDL.

Figure 6

Col1a1GFP (A–K) and wild-type (L) mouse livers were analyzed by immunohistochemistry. (A) ENTPD2 is expressed in GFP+ myofibroblasts around the bile duct (bd, arrowheads). (B) ACTA2 is expressed in GFP+ PFs (arrowheads) adjacent to the bile duct. Not all GFP+ PFs express ACTA2. (C) ACTA2 expression in GFP+ HSCs (arrows). (D,E) GFP+ MCs express KRT19 but not EPCAM (double arrowheads). (F–I) A few KRT19+ or EPCAM+ biliary epithelial cells in the small bile duct express GFP (double arrows). (J) The deposition of ELN is observed around the bile duct (arrowheads) and beneath the GFP+ MCs (double arrowheads). (K) RELN is expressed in GFP+ HSCs in the sinusoid (arrows). (L) MSLN is exclusively expressed in PDPN+ MCs (double arrowheads) but not in PFs around the portal vein (pv). Bar: 10 µm.