. Author manuscript; available in PMC: 2017 May 1.

Published in final edited form as: Int J Radiat Oncol Biol Phys. 2015 Nov 10;95(1):523–533. doi: 10.1016/j.ijrobp.2015.11.002

Table 3.

Improvement of Plan Robustness in the Face of Uncertainties and CTV Under-dosage Due to Interplay Effect vs. the Dimensionlessless Ratio of the Cube of Respiratory Motion Amplitude (RMA) Over CTV Volume (TV)

Patients	RMA³/(TV×10⁻⁴)	CTV Plan Robustness Improvement (%) (AUC_3D−AUC_4D)/ AUC_3D	Improvement of Mitigation of Interplay Effect on CTV (D_95%,4D−D_{95%, 3D})/ D_95%,3D (%)
1	11.34	14.59	1.01
2	25.16	24.75	0.15
3	1.13	4.47	0.15
4	45.17	9.98	0.47
5	9.21	39.57	0.19
6	70.21	17.53	1.19
7	6.46	24.01	2.77
8	0.16	50.62	−0.47
9	0.22	12.20	0.29
10	1.08	26.12	0.59
11	2.25	14.44	5.37

TV: Clinical Target Volume; RMA: respiratory motion amplitude; AUC: Area under RVH curve; RVH: root-mean-square dose volume histogram