Figure 3.

Photomontage of a motor neuron from the spinal cord of a 4-month-old tbl/tbl mouse. Arrows indicate lysosomes with different degrees of evolution distributed throughout the cell soma and dendritic cytoplasm (A–D). Multivesicular bodies (mb), incipient autophagosomes (arrowhead), and empty vacuoles are often observed near the lysosomes (B–D). Note that axosomatic and axodendritic synapses present an unaltered morphology (asterisks in A). Bars = 5 μm (A), 1 μm (B), and 0.5 μm (C,D).