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Coronal sections through the frontal cerebral cortex of 4-month-old tbl/tbl mice. 1.5 μm thick sections illustrate dark degenerative accumulations in both pyramidal cell somata (arrows in B–D) and apical dendrites (arrow in B). Cytoplasmic inclusion with characteristics of autophagosomes (arrowhead in H; e) and lysosomes (arrows in H; f,g) are observed within the pyramidal cell bodies. Bars = 100 μm (A), 20 μm (B–D), 2 μm (E), and 0.5 μm (E–G).
