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. 2016 Apr 18;10:156. doi: 10.3389/fnins.2016.00156

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Copyright © 2016 Özcan and Çakır.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Recontruction of the GBM metabolic models. GBM gene expression data were integrated with the growth-implemented brain specific genome-scale metabolic model (iMS570^g) by GIMME and MADE algorithms to create GBM metabolic models. The algorithms are shown in paranthesis for related GBM metabolic models. (Mes, Mesenchymal subtype of GBM; PN, ProNeural subtype of GBM; Pro, Proliferative subtype of GBM). GIMME and MADE sketches were obtained from Figure 1 of Blazier and Papin (2012).