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. Author manuscript; available in PMC: 2016 Apr 18.
Published in final edited form as: Inhal Toxicol. 2015;27(14):832–840. doi: 10.3109/08958378.2015.1117549

Table 1.

Experimental design.

Study Exposure
duration
(min)		 Number of
phosgene
exposed
animals		 Number
of sham
animals		 Clinical
observation time
points (h)		 Quality of
life scores
(Y/N)		 Scheduled
sacrifices (time
post-challenge)		 Body and
wet lung
weights
(Y/N)		 Gross necropsy
and histopathology
(Y/N) (n)
Lethality 10–30 249 214 1, 2, 4, 6, 8, 24 and 48 N 0, 4, 6, 8, 12, 24, and 48 h Y Y (84)
Model Development 34 185 55 1, 2, 4, 6, 8, 12, 15, 18, 21, 24, 36 and 48 Y 0, 2, 4, 6, 8, 12, 18, 24, 48 h, 5 and 7 days Y Y (156)