Table 2.
Partial correlations (p) between OFC grey matter volume or OFC asymmetry and residual symptom change and IGT performance after covarying for whole brain volume and/or age.
| CBTp+SC group |
Healthy participant group |
|||||||
|---|---|---|---|---|---|---|---|---|
| Baseline ROI variable | Total | Left | Right | Asymmetry | Total | Left | Right | Asymmetry |
| PANSS Total | 0.439 (0.03) | 0.302 (0.10) | 0.518 (0.01) | 0.537 (0.01) | – | – | – | – |
| PANSS Positive | 0.530 (0.01) | 0.496 (0.01) | 0.553 (0.01) | 0.308 (0.09) | – | – | – | – |
| PANSS Negative | 0.306 (0.10) | 0.146 (0.28) | 0.379 (0.05) | 0.542 (0.01) | – | – | – | – |
| PANSS General psychopathology | 0.347 (0.07) | 0.209 (0.20) | 0.440 (0.03) | 0.482 (0.02) | – | – | – | – |
| Pre-therapy IGT overall learninga | 0.177 (0.23) | 0.126 (0.30) | 0.253 (0.15) | 0.280 (0.12) | 0.074 (0.38) | −0.008 (0.49) | 0.161 (0.26) | 0.417 (0.04) |
| Pre-therapy IGT attention to rewarda | −0.439 (0.03) | −0.472 (0.02) | −0.351 (0.07) | −0.061 (0.40) | −0.050 (0.42) | −0.085 (0.37) | −0.010 (0.48) | 0.160 (0.26) |
| Pre-therapy IGT memory for past relative to recent outcomesa | −0.087 (0.36) | −0.121 (0.31) | −0.075 (0.38) | 0.051 (0.41) | 0.215 (0.20)b | 0.216 (0.19)b | 0.286 (0.12)b | −0.034 (0.44)b |
| Pre-therapy IGT choice consistencya | −0.100 (0.34) | −0.090 (0.36) | −0.077 (0.38) | −0.023 (0.46) | −0.501 (0.02) | −0.466 (0.03) | −0.519 (0.01) | 0.035 (0.44) |
Partial correlations were performed between OFC GMV and PANSS total and subscale scores and IGT performance while covarying for whole brain volume and age; partial correlations were performed between OFC rightward asymmetry and PANSS total and subscale scores and IGT performance while covarying for age.
a
Correlations based on 21 CBTp+SC patients and 21 healthy participants.
b
Spearman partial correlation was performed for IGT memory for past relative to recent outcomes because data transformation could not normalize data.