Table 1.
Demographic and clinical characteristics.
|
Baseline |
Follow-up |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| HC (n=93) | HR-well (n=92) | HR-MDD (n=19) | Statistics | HC (n=62) | HR-well (n=63) | HR-MDD (n=20) | Statistics | |||
| Mean (SD) | Mean (SD) | Mean (SD) | F/χ2 | p | Mean (SD) | Mean (SD) | Mean (SD) | F/χ2 | p | |
| Age (years) | 21.01 (2.45) | 21.20 (2.88) | 21.10 (2.82) | 0.13 | 0.88 | 22.82 (2.73) | 23.71 (2.84) | 23.33 (2.98) | 1.77 | 0.17 |
| Gender (M:F) | 40:53 | 44:48 | 9:10 | 0.46 | 0.80 | 21:41 | 29:34 | 7:13 | 2.12 | 0.35 |
| Handedness (Right:other) | 88:5 | 81:11 | 19:0 | 5.54 | 0.24 | 61:1 | 57:6 | 20:0 | 5.43 | 0.07 |
| NART IQ | 110.31 (8.00) | 108.39 (9.37) | 107.26 (6.80) | 1.64 | 0.20 | – | – | – | – | – |
| Time (years) | 2.13 (0.22) | 2.15 (0.22) | 2.10 (0.13) | 0.20 | 0.82 | – | – | – | – | – |
| HAM-Db | 0 (1) | 0 (2) | 1 (5) | 9.79 | 0.01a | 1 (3) | 1 (2) | 5 (12) | 7.59 | 0.02a |
| YMRSb | 0 (0) | 0 (0) | 0 (0) | 3.48 | 0.18 | 0 (0) | 0 (1) | 0 (0) | 0.79 | 0.68 |
Abbreviations: F, female; HAM-D, Hamilton Depression Rating Scale; HC, unaffected healthy control subjects; HR, high risk; HR-MDD, individuals at high risk for mood disorders who were well at baseline but developed major depressive disorder during the follow-up period; HR-well, individuals at high risk of mood disorders who were well at baseline and remained well during the follow-up period; M, male; NART, National Adult Reading Test; Time, Time between baseline and follow-up assessment; YMRS, Young Mania Rating Scale.
a
Significant effect.
b
Kruskal-Wallis test, median and interquartile presented for skewed variables.