Table 3.

Correlation between regional subcortical volumes and severity of depressive symptoms.

	HC (n=93)		HR-well (n=92)		HR-MDD (n=19)
Region	R	p	R	p	R	p
L lat ventricle	−0.06	0.71	0.10	0.51	0.22	0.44
R lat ventricle	−0.19	0.43	0.13	0.37	0.20	0.48
L caudate	−0.11	0.47	0.27	0.06	0.04	0.88
R caudate	−0.13	0.40	0.27	0.06	0.02	0.95
L putamen	−0.16	0.29	0.05	0.74	0.02	0.94
R putamen	−0.15	0.31	0.30	0.04	−0.10	0.72
L pallidum	−0.05	0.75	0.28	0.05	0.19	0.51
R pallidum	−0.20	0.18	0.13	0.36	0.31	0.26
L thalamus	−0.11	0.47	0.37	0.01	0.11	0.69
R thalamus	−0.18	0.23	0.07	0.64	0.22	0.43
L hippocampus	−0.06	0.71	0.19	0.19	0.15	0.59
R hippocampus	−0.17	0.26	0.31	0.03	0.28	0.32
L amygdala	0.02	0.91	−0.05	0.74	−0.07	0.80
R amygdala	−0.12	0.48	0.03	0.86	0.37	0.17

p-values are presented uncorrected for multiple comparison. Abbreviations: HC, unaffected healthy control subjects; HR-MDD, individuals at high risk for mood disorders who were well at baseline but developed major depressive disorder during the follow-up period; HR-well, individuals at high risk of mood disorders who were well at baseline and remained well during the follow-up period; L, left; lat, lateral; R, right.