Table 1.

Category	Mechamism	Example	Reference
Metabolism	Augment fatty acid oxidation	Overexpression of PPARα	54
	Augment electron transport chain	CoQ10 (ubiquinone)	55
Reactive oxygen species	Mitochondrial antioxidant	MitoQ	57, 58, 59
		SS-31	60, 61
Membrane permeability transitionpore	Inhibit Cyclophilin D (component of MPT)	Cyclosporine	65, 66
Mitochondrial dynamics	Inhibit Mitochondrial fission	siRNA knowndown of Drp1	69
Mitophagy	Activate mTOR to enhance autophagy	Tersirolimus	72
Mitochondrial biogenesis	Enhance nuclear transcription of mitochondrial proteins	PPARγ- coactivator- 1α (PGC1α)	46
	Activate β- Adrenergic receptors	Formoterol	79, 80