Table 1.
Associations between specific SNPs and orofacial TD in the Dutch and Siberian schizophrenic populations.
| Receptor | SNP | Dutch population |
Siberian schizophrenic population |
|
|---|---|---|---|---|
| TDof (B, P value) | TDof (OR (95% CI), P value) | TD expression level: sum of scores for 1–4 signs (P valuea) | ||
| GRIN2B | rs220599 | X | X | P = 0.04451 |
| GRIN2A | rs7192557 | B = 0.22, P = 0.0291 | X | X |
| rs1650420 | B = 0.16, P = 0.0336 | X | X | |
| rs11646587 | X | OR = 0.62 (0.38–1.00), P = 0.04652 | X | |
| rs7206256 | X | OR = 1.73 (1.02–2.91), P = 0.03570 | X | |
| rs1345423 | X | OR = 0.35 (0.14–0.86), P = 0.01043 | P = 0.027865 | |
| DRD3 | rs167770 | X | P = 0.01751 | X |
| HTR2C | rs4911871 | B = −0.18, P = 0.0131 | X | X |
TDof: orofacial tardive dyskinesia; OR: odds ratio; 95% CI: 95% confidence interval.
B = regression coefficient, P = chance, sum of scores = scores of AIMS scale.
a
Original value + 1, followed by log2-transformation.