Table 2.
Associations between specific SNPs and TDlt in the Dutch and Siberian schizophrenic populations.
| Receptor | SNP | Dutch population |
Siberian schizophrenic population |
|
|---|---|---|---|---|
| TDlt (B, P value) | TDlt (OR (95% CI), P value) | TD expression level: sum of scores for 5–7 signs (P valuea) | ||
| GRIN2A | rs1345423 | B = −0.18, P = 0.0190 | X | P = 0.02504 |
| rs7192557 | B = 0.22, P = 0.0430 | X | X | |
| rs1650420 | B = 0.16, P = 0.0471 | X | X | |
| rs11866328 | B = 0.16, P = 0.0330 | X | X | |
| rs7190619 | X | OR = 0.44[0.19–1.03], P = 0.04292 | P = 0.02510 | |
| rs9788936 | X | OR = 0.51[0.27–1.00], P = 0.04020 | X | |
| rs11644461 | X | X | P = 0.03875 | |
| DRD3 | rs963468 | X | X | P = 0.01533 |
| rs167770 | X | X | P = 0.012236 | |
TDlt: limb-truncal tardive dyskinesia; OR = odds ratio; 95% CI = 95% confidence interval.
Bold italics are statistically significant in both populations.
B = regression coefficient, P = chance, sum of scores = scores of AIMS scale.
a
Original value + 1, followed by log2-transformation.