Table 3.
Associations between specific SNPs and either type of TD in the Dutch and Siberian schizophrenic populations.
Receptor | SNP | Dutch population |
Siberian schizophrenic population |
|
---|---|---|---|---|
TD (B, P value) | TD (OR (95% CI), P value) | TD expression level: sum of scores for 1–7 signs (P valuea) | ||
GRIN2B | rs2192970 | X | OR = 1.93 (1.22–3.06), P = 0.005411 | X |
GRIN2A | rs1345423 | B = −0.13, P = 0.0421 | OR = 0.42 (0.20–0.89), P = 0.015210 | P = 0.014524 |
rs7192557 | B = 0.22, P = 0.0159 | X | X | |
rs1650420 | B = 0.16, P = 0.0193 | X | X | |
rs11644461 | B = −0.13, P = 0.0385 | X | X | |
DRD3 | rs324035 | X | X | P = 0.03211 |
rs167770 | X | X | P = 0.02197 |
OR: odds ratio; 95% CI: 95% confidence interval.
Bold italics are statistically significant in both populations.
B = regression coefficient, P = chance, sum of scores = scores of AIMS scale.
Original value + 1, followed by log2-transformation.