Table 4.

Association of Restless Legs Syndrome to History of Pregnancy-Induced Hypertension Alone and in Combination with Obesity, Diabetes, Cardiovascular Disease, and Gestational Diabetes

	Likelihood of meeting criteria for RLS
Association of history of GDM to RLS (n = 122 RLS cases)	OR (95% CI)a	p
History of PIH, by obesity		0.01
No PIH, no obesity	1.00 (referent)
PIH only (no obesity)	2.91 (1.25, 6.8)	0.01
Obesity only (no history of PIH)	1.80 (1.1, 2.93)	0.02
Both obesity and history of PIH	2.63 (1.20, 5.77)	0.02
p for interaction		NS
History of PIH, by diagnosis of CVD		0.003
No PIH, no CVD	1.00 (referent)
PIH only (no CVD)	1.72 (0.95, 3.18)	0.08
CVD only (no history of PIH)	1.29 (0.67, 4.83)	0.43
History of both PIH and CVD	4.71 (1.12, 20.07)	0.04
p for interaction		NS
History of PIH, by diagnosis of diabetes		0.007
No PIH, no diabetes	1.00 (referent)
PIH only (no diabetes)	1.70 (0.94, 3.05)	0.07
Diabetes only (no history of PIH)	1.54 (0.80, 3.10)	0.20
Both history of PIH and diabetes	5.71 (1.95, 16.72	0.001
p for interaction		NS
History of PIH, by history of GDM		0.003
No PIH, no GDM	1.00 (referent)
PIH only (no GDM)	2.11 (1.09, 4.09)	0.03
GDM only (no history of PIH)	3.49 (1.56, 7.83)	0.002
History of both PIH and GDM	2.73 (0.95, 7.89)	0.06
p for interaction		NS

n = 498 nonpregnant women ≥40 years of age attending four WVU primary care clinics. All p-values are two sided.

NS (p ≥ 0.1).

^aAdjusted for demographics, lifestyle characteristics, and BMI.

GDM, gestational diabetes; WVU, West Virginia University.