Table 1.

Changes in the bulge A region of internal ribosome entry site in tissues harvested from Toca 511–treated BALB/c mice

Animal	Treatment	Source of gDNA	Changes in bulge A (excluding other mutations such as recombination)
1	i.v. Toca 511	Thymus	Contraction of 7(A) to 6(A) in IRES accompanied by deletion in CD
			Expansion of 7(A) to 8(A) in IRES
			Expansion of 7(A) to 9(A) in IRES
2	i.v. Toca 511	Lymph node	Expansion of 7(A) to 10(A) in IRES
			Expansion of 7(A) to 11(A) in IRES
3	i.v. Toca 511	Thymus	Expansion of 7(A) to 8(A) in IRES

IRES, internal ribosome entry site; gDNA, genomic DNA.