Table 4.
Mutation rate in the A bulge from different infection cycles in vitro
| Plasmid DNA | |
|---|---|
| 4A | 4A (11/11) |
| 5A | 5A (12/12) |
| 6A | 6A (11/11) |
| 7A | 7A (12/12) |
| 8A | 8A (12/12) |
| 10A | 9A (1/11); 10A (10/11) |
| 12A | 8A (1/11); 12A (10/11) |
| Proviral DNA from infection cycle 7 | |
|---|---|
| 4A | 4A (10/10) |
| 5A | 5A (10/10) |
| 6A | 6A (8/10); 7A (2/10) |
| 7A | 7A (7/10); 8A (2/10); 10A (1/10) |
| 8A | 7A (1/10); 8A (3/10); 9A (1/10); 10A (1/10); 11A (2/10); 18A (1/10)l 22A (1/10) |
| 10A | 12A (1/10); 13A (2/10); 14A (1/10); 15A (1/10); 18A (2/10); 20A (1/10); 22A (1/10); 25A (1/10) |
| 12A | 13A (1/10); 18A (2/10); 20A (1/10); 27A (1/10); 28A (1/10); 31A (2/10); 39A (1/10); 54A (1/10) |
| Proviral DNA from infection cycle 10 | |
|---|---|
| 4A | 4A (10/10) |
| 5A | 5A (10/10) |
| 6A | 6A (10/12); 7A (2/12) |
| 7A | 7A (10/15); 8A (5/15) |
| 8A | 7A (2/13); 8A(4/13); 9A (3/13); 10A (1/3); 11A (1/13); 12A (1/13); 12A (2/13) |
| 10A | 11A (3/10); 20A (1/10); 30A (2/10); 40A (1/10); 53A (2/10); 54A (1/10) |
| 12A | 26A (4/10); 27A (1/10); 29A (2/10); 32A(1/10); 36A (1/10); 55A (1/10) |