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. 2016 Apr 18;6:23476. doi: 10.1038/srep23476

Figure 4. HFD-fed MNK1- or MNK2-KO mice show better glucose tolerance.

Figure 4

(a) Glucose tolerance test. After 15 weeks on either chow or the HFD, mice were fasted overnight before receiving an intraperitoneal injection of 2 g/kg glucose, and blood samples were taken at the indicated times (n = 6–21). Data are mean ± SEM. (b) Area under the curve calculations (AUC) (n = 6–21). Data are mean ± SEM (two-way ANOVA with Tukey’s post-test). (c) Insulin action test. After 20 weeks on either chow or HFD, the mice were fasted overnight before receiving an intraperitoneal injection of 0.75 U/kg insulin, and blood samples were taken at 30 min (n = 3–4). Data are mean ± SEM (2-tailed, unpaired Student’s t test) *P < 0.05, **P < 0.01.