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. 2016 Apr 18;6:23476. doi: 10.1038/srep23476

Figure 8. Analysis of expression of selected genes in liver of WT and MNK2-KO mice.

Figure 8

(a,b) Total RNA was isolated from liver tissue from chow-fed and HFD-fed WT and MNK2-KO mice. The relative expression of NRF2 and its downstream target heme oxygenase 1 (HO1) was measured by means of qPCR (n = 4). Data are mean ± SEM (2-tailed, unpaired Student’s t test comparing WT/HFD vs MNK2-KO/HFD) *P < 0.05. (c–f) The relative expression of genes involved in de novo lipogenesis (SREBP1c, FAS, ACC1) and β-oxidation (CPT1A) in the liver from chow-fed and HFD-fed WT and MNK2-KO mice were measured by qPCR (n = 4). Data are mean ± SEM relative to WT chow (2-tailed, unpaired Student’s t test) *P < 0.05, **P < 0.01.