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. 2016 Apr 18;6:24168. doi: 10.1038/srep24168

Figure 5. Early-onset overweight with early-onset obesity induces glucose intolerance and mild hyperinsulinemia.

Figure 5

(A,B) Intraperitoneal glucose tolerance test (i.p. GTT) at postnatal day 21 (A) and 70 (B) (P21 and P70); blood glucose levels (mg/dl) 0, 15, 30, 60, and 120 min after i.p. injection of glucose. P21: Ctrl, n = 12 from 5 litters; pHAmouse: n = 6 from 6 litters: P70: Ctrl: n = 7 from 3 litters; pHAmouse: n = 16 from 5 litters. two way ANOVA test and Bonferroni posttest. Early postnatal hyperalimentation (open square; pHAmousegroup), Ctrl (solid square; Ctrl). (C,D) Serum levels of insulin (ng/ml) at P21 (C): Ctrl: n = 7 from 5 litters; pHAmouse: n = 7 from 6 litters, and P70 (D): Ctrl: n = 5 from 4 litters; pHAmouse, n = 6 from 3 litters. Mann Whitney test; *p < 0.05, **p < 0.01, ***p < 0.001; n.s. = not significant.