Table 5.

Test of effect for covariates in the linear mixed model of fold‐change from baseline

Biomarker	P value for test of effect
	Baseline	Time	Treatment	Time × treatment
VEGF‐A	<0.001	0.941	<0.001	0.032
VEGF‐D	<0.001	<0.001	<0.001	<0.001
sVEGFR1	<0.001	0.997	0.484	0.218
sVEGFR2	<0.001	0.059	0.027	0.015
COL‐IV	<0.001	0.011	<0.001	<0.001
PLGF	<0.001	0.014	0.713	0.966
c‐Kit	<0.001	0.089	0.414	0.022

COL‐IV, collagen type IV; PLGF, placental growth factor; VEGF‐A, vascular endothelial growth factor A; VEGF‐D, vascular endothelial growth factor D; sVEGFR1, soluble VEGF receptor 1; sVEGFR2, soluble VEGF receptor 2.