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. 2016 Apr 14;7:11248. doi: 10.1038/ncomms11248

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(a) A visual guide to the annotations used for indicating specific functional groups in the bile acids chemical formulas (b–h) Inhibition of lysoPLD ATX activity measured as released choline by LPC(18:1) hydrolysis in the presence of specific bile salts with different steroid moiety hydroxylation patterns and acidic tail conjugations. The 12-OH substitution is not tolerated while the conjugation does not affect activity. The grey, blue and red circles highlight the hydroxylation of the steroid backbone; the orange and blue boxes highlight the conjugation partner. The error bars represent s.e.m. from triplicate experiments. Conc, concentration.