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. 2016 Apr 14;7:11228. doi: 10.1038/ncomms11228

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Ca accumulation and calcite precipitation are spatially and temporally separated. Calcium uptake into cells involves Ca transporter. The Ca ions are concentrated by polyphosphates into a disordered phase in a compartment distinct from the coccolith vesicle–reticular body system. The disordered Ca phase is a dynamic reservoir, concentrating and dispatching Ca ions. The released Ca ions are possibly transferred into the coccolith vesicle–reticular body system by Ca transporter and/or passive diffusion driven by a high-concentration gradient in free Ca ions. Inside the coccolith vesicle the calcium is precipitated as calcite.