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. 2016 Feb 16;7(4):351–356. doi: 10.1021/acsmedchemlett.6b00005

Figure 1.

Figure 1

CNS penetration of 16 in rat and mouse. [Brain]/[Plasma] ratios determined after oral dose of 16 to female CD-1 mice or male Sprague–Dawley rats as an MCT suspension. *[Brain]u and [Plasma]u refer to the unbound concentration measured in the brain and plasma, respectively. **[CSF] refers to the concentration measured in the cerebral spinal fluid. aDetermined to be identical at both 1 and 6 h after administration of 25 mg/kg 16 to female CD-1 mice. The [Brain]/[Plasma] ratios are the mean values from 3 animals per time point. bDetermined after administration of 15 mg/kg 16 to male Sprague–Dawley rats. [Brain]/[Plasma] determined for 1 animal at each of 0.25 and 2 h and 3 at 8 h. Data reported are the range across the three time points (average of the 3 animals at 8 h). c[CSF] determined for 1 animal at each of 0.25 and 2 h and 3 at 8 h. Data reported are the range across the three time points (average of the 3 animals at 8 h).