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Inhibition of p-AKT by 16 in normal mouse brain tissue along with corresponding brain and unbound brain concentrations. *Significantly different from untreated control. p < 0.05, t test. [Brain] determined after 25 mg/kg oral dose of 16 female CD-1 mice as an MCT suspension. [Brain]u refers to the unbound concentration measured in the brain. Data are reported as mean values ± SD from 3 animals per time point.
