. 2016 Feb 16;7(4):351–356. doi: 10.1021/acsmedchemlett.6b00005

Table 4. Preclinical Species Hepatocyte Stability and in Vivo Pharmacokinetic Data for 16.

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		IV (1 mg/kg)^b		PO^c
Species	liver microsomes Cl_hep (mL/min/kg)^a	in vivo Cl (mL/min/kg)	Vss (L/kg)	Dose (mg/kg)	AUC (μM·h)	F%	PPB%
Mouse	19	17	1.7	25	47	75	78
Rat	14	28	3.2	5	8.3	77	71

Hepatic clearance was predicted from liver microsomes incubations using the “in vitro t_1/2 method.”⁹

Male Sprague–Dawley rats or female CD-1 mice were dosed intravenously with 1 mg/kg of 16 prepared in 60% PEG400/10% ethanol.

Compound 16 was administered PO at the indicated dose in 0.5% methylcellulose with 0.2% Tween 80 (MCT).