Table 3. Investigation of putative upstream regulators.

Differentially expressed transcripts in differentiated Schwann cells were analyzed in respect to their potential upstream regulators.

Upstream regulator	Common name	Predicted activation state	Activation z-score	P-value of overlap
Forskolin		Activated	2.508	3.90×10−15
CHUK	Inhibitor of nuclear factor kappa-B kinase subunit α	Activated	2.387	4.83×10−15
IKBKG	Inhibitor of kappaB kinase subunit γ	Activated	2.982	1.61×10−13
IKBKB	Inhibitor of kappaB kinase subunit β	Activated	2.985	1.21×10−10
STAT3	Signal transducer and activator of transcription 3	Activated	2.462	8.81×10−7
CEBPB	C/EBP-beta, NF-IL6	Activated	2.201	5.81×10−6
SOX10	SRY-box containing gene 10	Activated	2.200	1.57×10−5
HOXC8	Homeobox C8	Activated	2.000	6.41×10−3
Tnf (family)	Tumor necrosis factor	Activated	2.132	9.84×10−3
HOXC6	Homeobox C6	Activated	2.000	1.51×10−2
ZNF217	Zinc finger protein 217	Activated	2.236	3.36×10−2
PTPRJ	Protein tyrosine phosphatase, receptor type, J	Activated	2.000	4.33×10−2
NOTCH1	Notch1	Inhibited	−2.318	8.05×10−6
SRF	Serum response factor	Inhibited	−2.668	1.12×10−5
TGFB3	Transforming growth factor, β 3	Inhibited	−2.559	3.31×10−5
KLF4	Kruppel-like factor 4	Inhibited	−2.599	5.93×10−4
Nfat (family)	Nuclear factor of activated T cells	Inhibited	−2.121	6.60×10−4
LYN	Yamaguchi sarcoma viral (v-yes-1) oncogene homolog	Inhibited	−2.186	4.21×10−3
RAC1	RAS-related C3 botulinum substrate 1	Inhibited	−2.173	5.11×10−3
MAP2K1/2	Mek1/2	Inhibited	−2.177	9.43×10−3
MKL1	MKL (megakaryoblastic leukemia)/myocardin-like 1	Inhibited	−2.160	1.26×10−2
SFTPA1	Surfactant associated protein A1	Inhibited	−2.200	3.19×10−2
IKZF1	IKAROS family zinc finger 1	Inhibited	−2.433	3.92×10−2