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. 2016 Jan 26;63(4):1256–1271. doi: 10.1002/hep.28417

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© 2015 The Authors. Hepatology published by Wiley Periodicals, Inc., on behalf of American Association for the Study of Liver Diseases.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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ACTL6A activates Notch signaling in HCC. (A) The 10‐Pathway Reporter Array showed the signaling change in ACTL6A‐interfered cells. (B) The four known Notch receptors' mRNA expression were detected by real‐time PCR. (C) Key members of Notch1 signaling expressions were detected by western blotting. (D) NICD1 and Hes1 expression in HCC cells after being treated by ACTL6A, shACTL6A, and/or DAPT for 72 hours were detected. (E) Representative IHC images of ACTL6A and NICD1 expression in HCC tissues; magnification: 100×, inset magnification: 400×. (F) Correlation of ACTL6A and NICD1 expression levels was analyzed by Spearman's rank correlation test. Abbreviations: ERK, extracelullar signal‐regulated kinase; JNK, c‐Jun N‐terminal kinase; MAPK, mitogen‐activated protein kinase; NF‐κB, nuclear factor kappa B; TGF‐β, transforming growth factor beta.