Table 2.
Characteristics of included patients
| Trial | AIMT arm | Medical care (intravenous rt-PA) arm | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Intervention | No of patients* | Mean (SD) age (years) | No (%) men | Mean (SD) NIHSS | Intervention | No of patients* | Mean (SD) age (years) | No (%) men | Mean (SD) NIHSS | ||
| IMS III28 | IV rt-PA with or without IV heparin with or without thrombectomy and/or IA rt-PA | 434 | 63 (SD) 11.07 | 218 (50.2) | 20 (SD) 5.54 | IV rt-PA | 222 | 61 (SD) 10.23 | 122 (55.0) | 18 (SD) 3.69 | |
| SYNTHESIS29 | IV heparin with or without thrombectomy and/or IA rt-PA | 181 | 66 (SD) 11 | 106 (59) | 13 (SD) 5.98 | IV rt-PA | 181 | 67 (SD) 11 | 103 (57) | 13 (SD) 6.73 | |
| MR RESCUE30 | Thrombectomy with or without IA rt-PA with or without IV heparin with or without IV rt-PA | 70*/64† | 64 (SD) 12.78† | 30 (46.9)† | 17 (SD) 4.72† | With or without IV rt-PA | 57*/54† | 67 (SD) 16.48† | 27 (50)† | 17 (SD) 5.73† | |
| MR CLEAN31 | With or without IV rt-PA+thrombectomy with or without IA rt-PA or IA uPA | 233 | 65 (SD) 16.04 | 135 (57.9) | 17 (SD) 5.22 | With or without IV rt-PA | 267 | 66 (SD) 15.58 | 157 (58.8) | 18 (SD) 5.96 | |
| ESCAPE32 | Thrombectomy with or without IV rt-PA | 165 | 71 (SD) 15.71 | 79 (47.9) | 16 (SD) 5.24 | With or without IV rt-PA | 150 | 70 (SD) 15.72 | 71 (47.3) | 16 (SD) 5.99 | |
| EXTEND-IA33 | IV rt-PA with or without thrombectomy | 35 | 69 (SD) 12.3 | 17 (49) | 17 (SD) 5.41 | IV rt-PA | 35 | 70 (SD) 11.8 | 17 (49) | 14 (SD) 7.73 | |
| SWIFT PRIME34 | IV rt-PA with or without thrombectomy | 98*/98‡ | 65 (SD) 12.5† | 54 (55.1)† | 17 (SD) 5.27† | IV rt-PA | 98*/93‡ | 66 (SD) 11.3† | 45 (48.4)† | 16 (SD) 4.52† | |
| REVASCAT35 | Thrombectomy with or without IV rt-PA | 103 | 66 (SD) 11.3 | 55 (53.4) | 17 (SD) 4.51 | With or without IV rt-PA | 103 | 67 (SD) 9.5 | 54 (52.4) | 16 (SD) 5.26 | |
| THERAPY36 | IV rt-PA with or without thrombectomy | 55 | 67 (SD) 11.4 | 34 (61.8) | 17 (SD) 6.05 | IV rt-PA | 53 | 70 (SD) 10.3 | 23 (43.9) | 18 (SD) 5.38 | |
| THRACE37 | IV rt-PA with or without thrombectomy | 190 | NS | NS | NS | IV rt-PA | 195 | NS | NS | NS | |
AIMT=adjuvant intra-arterial mechanical thrombolysis; IA=intra-arterial; IV=intravenous; NIHSS=National Institute of Health stroke scale; NS=not specified; rt-PA=recombinant tissue plasminogen activator; uPA=urokinase-type plasminogen activator.
*Intention to treat population.
†Modified intention to treat population.