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Effect of different doses of IPLT BiTox (2, 50, 100, 200 ng) on capsaicin-induced secondary hyperalgesia. Mechanical withdrawal thresholds measured with von Frey filaments (A) and withdrawal response duration (s) after pinprick stimulation (B). The measurements were assessed before injection and then 30 minutes, 1, and 2 hours after capsaicin injection. Data are expressed as means ± SEM, *P < 0.05, **P < 0.01. n = 4 to 6 animals per group.
