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. 2016 Jan 5;157(5):1045–1055. doi: 10.1097/j.pain.0000000000000478

Figure 7.

Figure 7

Intraplantar BiTox attenuates SNI-induced mechanical hypersensitivity but not cold hypersensitivity. BiTox (200 ng) or vehicle were injected IPLT 3 days after (A, C) SNI or 14 days before (B) SNI. Mechanical hyperalgesia was attenuated (A, B) but cold allodynia (C) was unaffected by treatment with BiTox injected 3 days after SNI. Baseline pain threshold (BL) was determined for 5 days before surgery or injection. Data are expressed as means ± SEM, **P < 0.01, ***P < 0.001 (A, B), P > 0.05 (C). n = 9 to 10 animals per group.