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. 2016 Jan 5;157(5):1045–1055. doi: 10.1097/j.pain.0000000000000478

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© 2016 International Association for the Study of Pain

This is an open access article distributed under the terms of the Creative Commons Attribution License 4.0 (CC BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Intraplantar BiTox blocks capsaicin-induced secondary mechanical hyperalgesia. BiTox (200 ng) or vehicle were injected into the lateral plantar surface of the rat hindpaw (A2). Three days later 0.3% capsaicin was injected into the central plantar area (A1) and mechanical secondary hyperalgesia was measured in the lateral zone. Mechanical withdrawal threshold measured with von Frey filaments (B) or withdrawal response duration after pinprick stimulus (C), were attenuated by BiTox pretreatment. The measurements were made before injection (BL) and then 30 minutes, 1 and 2 hours after capsaicin injection. Data are expressed as means ± SEM, *P < 0.05, ***P < 0.001. n = 6 animals per group.