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. 2016 Apr 18;47:50. doi: 10.1186/s13567-016-0334-0

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© Yi et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Protective efficacy by vaccination in mice. Mice were injected with S. equi spp. zooepidemicus ATCC35246 and mortality was recorded daily for 7 days. Mice in the non-immunized group died 24 to 48 h after the challenge, and the mortality rate reached 100%. Mice in the groups immunized with rGroEL or the inactivated S. equi spp. zooepidemicus vaccine died 48 to 72 h after the challenge with S. equi spp. zooepidemicus and 75% survived 7 days post-infection for these two groups. Significant differences in survival were noted, log rank test, P < 0.05. Compared with the non-immunized group, the mice in the groups immunized with rGroEL or the inactivated S. equi spp. zooepidemicus vaccine had higher survival rates (P < 0.05).