Table 5.
Factors Associated with Changes in BMD and Bone Turnover Markers in the Caloric Restriction Group*
| Final model of variables affecting Δ spine BMD | ||
|---|---|---|
| at 12 months | ||
| β | p-value | |
| Δ cortisol | 0.248 | 0.004 |
| Δ 25OHD | 0.243 | 0.01 |
| Δ total energy intake | 0.206 | 0.02 |
| Δ FM | 0.210 | 0.02 |
| Δ FFM | −0.160 | 0.08 |
| at 24 months | ||
|---|---|---|
| β | p-value | |
| Δ total fat intake | 0.282 | 0.01 |
| Δ 25OHD | 0.218 | 0.02 |
| Δ total CHO intake | −0.193 | 0.07 |
| Final model of variables affecting Δ hip BMD | ||
|---|---|---|
| at 12 months | ||
| β | p-value | |
| Δ Cortisol | 0.393 | <.001 |
| Δ IGF-1 | −0.384 | <.001 |
| Δ adiponectin | −0.319 | <.001 |
| Δ leptin | −0.252 | 0.002 |
| Δ FFM | 0.179 | 0.02 |
| Δ total protein intake | 0.122 | 0.12 |
| at 24 months | ||
|---|---|---|
| β | p-value | |
| Δ FFM | 0.226 | 0.02 |
| Δ cortisol | 0.171 | 0.06 |
| Δ leptin | −0.143 | 0.11 |
| Final model of variables affecting Δ CTX | ||
|---|---|---|
| at 12 months | ||
| β | p-value | |
| Δ FFM | −0.266 | 0.003 |
| Δ IGF-1 | 0.248 | 0.005 |
| Δ Cortisol | −0.176 | 0.04 |
| Δ PA activity | −0.135 | 0.12 |
| at 24 months | ||
|---|---|---|
| β | p-value | |
| Δ FFM | −0.220 | 0.01 |
| Δ cortisol | −0.231 | 0.01 |
| Δ leptin | −0.240 | 0.01 |
| Δ total CHO intake | −0.236 | 0.01 |
| Final model of variables affecting Δ TRAP5b | ||
|---|---|---|
| at 12 months | ||
| β | p-value | |
| Δ FFM | −0.107 | 0.02 |
| Δ cortisol | −0.145 | 0.10 |
| Δ vitamin A intake | 0.165 | 0.10 |
| at 24 months | ||
|---|---|---|
| β | p-value | |
| Δ cortisol | −0.338 | <.001 |
| Δ leptin | −0.29 | <.001 |
| Δ FFM | −0.162 | 0.06 |
| Δ insulin | −0,145 | 0.09 |
| Final model of variables affecting Δ BAP | ||
|---|---|---|
| at 12 months | ||
| β | p-value | |
| Δ cortisol | −0.330 | 0.001 |
| Δ IGF-1 | 0.266 | 0.002 |
| Δ total energy intake | −0.125 | 0.14 |
| at 24 months | ||
|---|---|---|
| β | p-value | |
| Δ Cortisol | −0.263 | 0.004 |
| Δ IGF1 | 0.193 | 0.03 |
| Δ leptin | −0.158 | 0.08 |
| Δ PTH | −0.149 | 0.09 |
| Δ total energy intake | −0.134 | 0.14 |
| Final model of variables affecting Δ PINP | ||
|---|---|---|
| at 12 months | ||
| β | p-value | |
| Δ cortisol | −0.367 | <.001 |
| Δ IGF-1 | 0.279 | 0.001 |
| Δ total CHO intake | −0.275 | 0.001 |
| Δ weight | −0.260 | 0.002 |
| Δ 25OHD | −0.203 | 0.02 |
| at 24 months | ||
|---|---|---|
| β | p-value | |
| Δ total protein | −0.254 | 0.01 |
| Δ Cortisol | −0.250 | 0.01 |
| Δ IGF1 | 0.190 | 0.03 |
| Δ weight | −0.161 | 0.07 |
| Δ leptin | −0.140 | 0.12 |
multiple r=0.43; p<0.001
multiple r=0.31; p=0.01
multiple r=0.56; p<0.001
multiple r=0.31; p=0.01
multiple r=0.39; p=0.001
multiple r=0.51; p<.001
multiple r=0.26; p=.01
multiple r=0.55; p <.001
multiple r=0.41; p<.001
multiple r=0.55; p <.001
multiple r=0.56; p<.001
multiple r=0.52; p<.001
Abbreviations: Δ = change, BMD = bone mineral density, 25OHD = 25-hydroxyvitamin D, FM = fat mass, FFM = fat-free mass, CHO = carbohydrate, IGF-1 = insulin growth factor-1, CTX = C-telopeptide of type I collagen; BSAP = bone specific alkaline phosphatase; TRAP5b = Tartrate-resistant acid phosphatase; PINP = intact N-terminal propeptide of type I procollagen; PA = physical activity
Using stepwise multiple regression analyses