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. Author manuscript; available in PMC: 2016 Apr 18.
Published in final edited form as: Biol Psychiatry. 2012 Feb 17;71(10):890–897. doi: 10.1016/j.biopsych.2012.01.002

Figure 3.

Figure 3

(a) Direct comparison of patients with schizophrenia and healthy aging subjects. Data for brain regions significantly activated by 2-back relative to the 0-back conditions overlaid onto a 3D rendered brain for aging subjects>patients with schizophrenia and patients with schizophrenia>aging. Healthy aging subjects overactivated the left lateral PFC compared to patients with schizophrenia, whereas patients with schizophrenia did not activate any PFC region more than aging subjects. (b) Common findings in aging and schizophrenia. Conjunction analysis of patients with schizophrenia and healthy aging subjects overlaid on saggital and coronal slices. Decreased deactivation of the anterior medial PFC, parahippocampal region and posterior cingulate cortex were observed in both patients with schizophrenia and healthy aging subjects.