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. Author manuscript; available in PMC: 2017 Apr 15.
Published in final edited form as: Circ Res. 2016 Apr 15;118(8):1254–1263. doi: 10.1161/CIRCRESAHA.115.307347

Table 5.

Types of meta-analyses in cell-based cardiac regeneration

Meta-analysis Example Type Analysis type Advantage Disadvantage
Pooling all studies Jeevananthan20 RCT-Pb All studies analyzed
as one collective		 Large sample
size		 Large heterogeneity,
Missing data recalculated
Pooling certain studies
with predefined
inclusion criteria		 Clifford11 RCT-Pb Different studies in
subgroups		 Large sample size, but
lower number of patients
in subgroups		 Less heterogeneity,
Missing data recalculated
Pooling certain studies
with predefined
inclusion criteria		 Delewi13 RCT-Pb,
summary of
mean of
subgroups		 Different studies in
subgroups		 Large sample size, but
lower number of patients
in subgroups		 Less heterogeneity,
Missing data recalculated
Pooling certain studies
with predefined
inclusion criteria		 Gyöngyösi1 RCT-IPD All patients and
studies analyzed as
one collective		 Low heterogeneity,
Original data in database		 Lower number of patients and
studies

RCT indicates randomized controlled studies; Pb, publication-based; IPD, individual patient data-based.