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. Author manuscript; available in PMC: 2017 Apr 15.
Published in final edited form as: Circ Res. 2016 Apr 15;118(8):1327–1336. doi: 10.1161/CIRCRESAHA.116.307709

Figure 2. Short-chain fatty-acid receptors involved in blood pressure regulation are altered in the ileum of SHR.

Figure 2

SCFA receptors Olfr59 and Ffar3 are involved in BP regulation, to increase or decrease it, respectively79, 80. Intestinal bacteria are the main source of SCFAs112; therefore, we sought to examine the SCFA receptors in rat intestinal tissue. Ileum and colon tissues were excised for RNA extraction and RT-PCR from 20-week old WKY and SHR, as previously described5 (n=8 per group, MAP WKY: 99±3, MAP SHR: 158±2). We observed an increase in Olfr59 mRNA and a decrease in Ffar3 mRNA in the ileum, but not colon, of SHR.