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. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: Genet Med. 2015 Apr 9;18(1):13–19. doi: 10.1038/gim.2015.27

Table 1.

Published Cumulative Cancer Risks to Age 70 for Lynch syndrome

Cancer Site Cancer Risks for MLH1, MSH2 Cancer Risks MSH6 Cancer Risks for PMS2
Colorectal 28% - 75%[28-30] 10-70%[29, 31, 32] 15%-20%[16]
Endometrium 27% - 60%[28-30] 15-71%[29, 31, 32] 15%[16]
Ovary 6% - 21%[28, 29, 33, 34] 1%[29] increased risk
Urinary Tract 8% - 9%[28, 29, 33, 34] <1%[29] increased risk
Stomach 5% - 20%[28, 29, 33, 34] <1%[29] increased risk