Table 2.

Current Published Screening Guidelines for Lynch Syndrome

Cancer Site	Recommended Screening for MLH1, MSH2	Recommended Screening for MSH6	Recommended Screening for PMS2
Colon
NCCN[9]	- Colonoscopy every 1-2 years, beginning at age 20 to 25 years (or 2-5y prior to earliest colon cancer in family)	- Colonoscopy every 1-2 years, beginning at age 25 to 30 years (or 2-5y prior to earliest colon cancer if it is diagnosed before age 30 years)	- Colonoscopy every 1-2 years, beginning at age 25 to 30 years (or 2-5y prior to earliest colon cancer if it is diagnosed before age 30 years)
Other recommendations:	- Colonoscopy every 1-2 years[10]	- Colonoscopy every 1-2 years[10] - Colonoscopy every 1-2 years, beginning at age 30[35]	- Colonoscopy every 1-2 years, beginning at age 30[16] - Colonoscopy every 1-2 years, beginning at age 35[35]
Endometrium and Ovary
NCCN[9]	- Consideration of annual endometrial sampling offered annually - Consideration of transvaginal ultrasound and serum CA-125 - TAH BSO should be considered if childbearing is complete	- Consideration of annual endometrial sampling offered annually - Consideration of transvaginal ultrasound and serum CA-125 - TAH BSO should be considered if childbearing is complete	- Consideration of annual endometrial sampling offered annually - Consideration of transvaginal ultrasound and serum CA-125 - TAH BSO should be considered if childbearing is complete
Other recommendations:	- Gynecological exam, transvaginal ultrasound and endometrial sampling offered beginning at age 35 to 40 years[10] - TAH BSO should be considered[10] - Gynecological exam, transvaginal ultrasound and endometrial sampling offered beginning at age 30 to 35 years[35]	- Gynecological exam, transvaginal ultrasound and endometrial sampling offered beginning at age 35 to 40 years[10] - TAH BSO should be considered[10]
Urinary Tract
NCCN[9]	-Consideration of annual urinalysis, beginning at age 25 to 30 years
Other recommendations:	- Consideration of annual urinalysis, beginning at age 30 to 35 years[35]
Stomach
NCCN[9]	- Consideration of EGD with extended duodenoscopy every 3-5 years, beginning at age 30 to 35 years
Other recommendations:	- Consideration of EGD with biopsy of the gastric antrum every 2-3 years, beginning at age 30 to 35 years[35]