Table 3.
SNP | Chr. | Chr. location | Gene | Relative Pos. | Case |
Control |
Ptrenda | ORb | RAFb | Alleleb | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
11 | 12 | 22 | 11 | 12 | 22 | Case | Control | 1 | 2 | |||||||
rs17674580 | 18 | 43309911 | SLC14A1 | 0 | 5 | 86 | 439 | 28 | 579 | 4619 | 1.8 × 10−4 | 1.54 | 0.091 | 0.061 | A | G |
rs1014971 | 22 | 39332623 | APOBEC3A | −20904 | 117 | 256 | 157 | 920 | 2545 | 1761 | 0.0074 | 1.19 | 0.462 | 0.420 | T | C |
rs2294008 | 8 | 143761931 | PSCA | 0 | 241 | 228 | 61 | 2079 | 2416 | 730 | 0.0092 | 1.20 | 0.670 | 0.629 | T | C |
rs9642880 | 8 | 128718068 | MYC | −30247 | 63 | 226 | 241 | 491 | 2165 | 2569 | 0.039 | 1.15 | 0.332 | 0.301 | T | G |
rs798766 | 4 | 1734239 | TACC3 | 0 | 15 | 174 | 341 | 154 | 1461 | 3611 | 0.056 | 1.17 | 0.192 | 0.169 | A | G |
rs11892031 | 2 | 234565283 | UGT1A8 | 0 | 526 | 4 | 0 | 5143 | 83 | 0 | 0.13 | 2.11 | 0.996 | 0.992 | T | G |
rs1495741 | 8 | 18272881 | NAT2 | 14158 | 55 | 232 | 244 | 559 | 2394 | 2628 | 0.62 | 1.03 | 0.322 | 0.315 | A | G |
rs401681 | 5 | 1322087 | CLPTM1L | 0 | 229 | 245 | 56 | 2359 | 2288 | 579 | 0.64 | 0.97 | 0.663 | 0.670 | G | A |
rs710521 | 3 | 189645933 | LEPREL1 | 28584 | 298 | 203 | 29 | 2948 | 1996 | 282 | 0.92 | 0.99 | 0.754 | 0.755 | T | C |
rs8102137 | 19 | 30296853 | CCNE1 | −6048 | 2 | 89 | 439 | 37 | 834 | 4355 | 0.92 | 0.99 | 0.912 | 0.913 | G | A |
We analyzed 539 bladder cancer cases and 5581 controls at GWAS stage. Chr., chromosome; Pos., position in the NCBI Build 36.3.
P-values were obtained from Cochrane-Armitage trend test.
Allele 1 is a risk allele in the previous GWAS studies. OR was calculated using allele 2 as a reference.