TABLE 3.
Males | Females | |||||
---|---|---|---|---|---|---|
rP | rA (CI) | rE (CI) | rP | rA (CI) | rE (CI) | |
HDL-C | −0.01 | −0.09 (−0.32,0.11) | 0.22 (−0.08,0.48) | 0.20d | 0.17 (−0.09,0.42) | 0.21 (−0.04,0.43) |
HDL-C/LDL-C | −0.07 | −0.18 (−0.39,0.02) | 0.36 (0.09,0.57) | 0.19d | 0.16 (−0.06,0.36) | 0.16 (−0.07,0.37) |
HDL particle size | 0.01 | 0.01 (−0.18,0.20) | 0.16 (−0.11,0.41) | 0.21d | 0.18 (−0.01,0.37) | 0.23 (0.01,0.43) |
Medium HDL | −0.07 | −0.03 (−0.30,0.23) | 0.02 (−0.26,0.29) | 0.13b | 0.34 (0.06,0.65) | −0.02 (−0.24,0.21) |
Large HDL | 0.01 | −0.04 (−1.00,0.20) | 0.17 (−0.16,0.79) | 0.20d | 0.39 (0.04,1.00) | 0.04 (−0.51,0.32) |
Total HDL | −0.05 | −0.15 (−0.41,0.08) | 0.17 (−0.13,0.44) | 0.18d | 0.22 (−0.07,0.53) | 0.12 (−0.13,0.35) |
Apolipoprotein A1 | −0.01 | −0.06 (−0.28,0.16) | 0.07 (−0.22,0.35) | 0.11b | 0.08 (−0.26,0.44) | 0.11 (−0.14,0.35) |
ApoB/ApoA-1 | 0.03 | 0.19 (−0.02,0.44) | −0.36 (−0.60,−0.07) | −0.16c | 0.03 (−0.29,0.24) | −0.19 (−0.42,0.07) |
Phenotypic correlations (rP) were estimated using Pearson’s correlation method. Genetic (rA) and environmental (rE) correlations between pubertal timing and each of the analyzed lipids and lipoproteins were obtained from the multivariate Cholesky model, which decomposes phenotypic covariation into uncorrelated genetic and environmental factors. In each multivariate model, two phenotypes were included: PDS14 and one lipoprotein. CI, 95% confidence interval for rA and rE.
P<0.05
P<0.01
P<0.001.