Table 4.
Comparisons of cognitive function across amylin quartiles in the absence and presence of ApoE4 allele
| Amylin quartiles
|
|||||
|---|---|---|---|---|---|
| ApoE4 non-carriers | Quartile 1 n=209 |
Quartile 2 n= 214 |
Quartile 3 n= 207 |
Quartile 4 n= 206 |
p values |
| WLL delayed recall, mean±SD | 3.3±2.7 | 3.3±2.7 | 4.1±3.0 | 3.8 ±2.9 | 0.01 |
| LM delayed recall, mean±SD | 17.4±10.3 | 17.2±9.6 | 20.2±9.9 | 19.6±8.8 | 0.002 |
| Trailmaking A, mean±SD | 97.2±66.2 | 94.4±71.9 | 76.8±44.1 | 76.8±50.6 | 0.0007 |
| Trailmaking B, mean±SD | 222.8±79.6 | 213.7±83.3 | 204.5±83.8 | 200.5±85.6 | 0.05 |
| Block design, mean±SD | 18.9±8.8 | 19.8±8.9 | 20.6±9.0 | 22.3±10.0 | 0.005 |
| Amylin Quartiles | |||||
|
| |||||
| ApoE4 carriers | n=63 | n=61 | n=68 | n=65 | |
|
| |||||
| WLL delayed recall, mean±SD | 3.6±2.8 | 2.8±2.5 | 3.7±2.6 | 3.7±2.7 | 0.17 |
| LM delayed recall, mean±SD | 16.8±9.6 | 15.6±10.1 | 19.1±8.6 | 18.5±10.8 | 0.11 |
| Trailmaking A, mean±SD | 105.4±69.2 | 92.1±66.0 | 83.1±50.3 | 85.4±61.4 | 0.06 |
| Trailmaking B, mean±SD | 227.7±82.1 | 220.1±88.4 | 210.3±82.7 | 213.8±89.2 | 0.62 |
| Block design, mean±SD | 18.1±9.4 | 17.5±8.2 | 20.8±8.4 | 18.7±8.1 | 0.09 |
Subjects are divided into ApoE4 non-carriers and ApoE4 carriers in each amylin quartile. Mean±SD with ANOVA test is used to describe the distributions and comparisons of test scores in each cognitive domain across the amylin quartiles in the absence or in the presence of ApoE4. P values for the statistical significance are shown. WLL, Word learning list; LM, Logical memory.