Table 1. Methylation and metabolic measures.
| Measure | Rural Hyderabad |
Urban Hyderabad |
Rural Lucknow |
Urban Lucknow |
Urban Indian |
RISC RISC |
||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| n | Median (IQR) |
n | Median (IQR) |
n | Median (IQR) |
n | Median (IQR) |
n | Median (IQR) |
n | Median (IQR) |
|
| (%) ADCY5 | 63 | 96.6 | 66 | 96.8 | 83 | 96.7 | 89 | 96.7 | 155 | 96.8 | 332 | 90.5 |
| Methylation | - | (96.0-97.0) | - | (96.3-97.0) | - | (96.4-97.3) | - | (96.2-97.3) | - | (96.0-97.0) | - | (89.4-91.2) |
| (%) FTO | 80 | 8.0 | 80 | 8.0 | 89 | 8.5 | 90 | 8.7 | 170 | 8.5 | 336 | 5.8 |
| Methylation | - | (6.9-9.2) | - | (6.7-9.1) | - | (7.8-10.0) | - | (7.8-9.7) | - | (7.5-8.5) | - | (5.3-6.3) |
| (%) KCNJ11 | 78 | 96.0 | 79 | 96.2 | 88 | 95.5 | 86 | 95.7 | 165 | 95.8 | 337 | 94.3 |
| Methylation | - | (95.5-96.7) | - | (95.5-96.5) | - | (95.1-95.8) | - | (95.2-96.0) | - | (95.3-96.3) | - | (93.8-94.8) |
| Age | 91 | 46 | 91 | 47 | 91 | 45 | 91 | 46 | 182 | 46 | 351 | 44 |
| (years) | - | (41-52) | - | (42-51) | - | (41-50) | - | (43-50) | - | (42-50.5) | - | (38-51) |
| Sex (% male) | 91 | 52% | 91 | 52% | 91 | 77% | 91 | 77% | 182 | 64% | 351 | 43% |
| Fasting glucose | 91 | 4.94 | 91 | 5.05 | 91 | 5.22 | 91 | 5.55 | 182 | 5.18 | 350 | 5.15 |
| (mmol/L) | - | (4.66-5.16) | - | (4.72-5.27) | - | (4.76-5.80) | - | (4.94-6.27) | - | (4.83-5.72) | - | (4.80-5.50) |
| Fasting insulin | 91 | 3.80 | 91 | 6.00 | 91 | 5.00 | 90 | 6.75 | 181 | 6.20 | 348 | 4.61 |
| (mU/L) | - | (1.90-8.20) | - | (3.0-10.0) | - | (2.0-6.8) | - | (4.2-10.5) | - | (3.7-10.0) | - | (3.02-6.33) |
| HOMA-IR | 80 | 0.84 | 76 | 1.34 | 84 | 1.03 | 74 | 1.52 | 150 | 1.44 | 347 | 1.07 |
| - | (0.39-1.70) | - | (0.56-2.13) | - | (0.47-1.59) | - | (0.96-2.42) | - | (0.76-2.27) | - | (0.66-1.54) | |
| BMI | 91 | 23.40 | 91 | 25.98 | 91 | 20.90 | 91 | 25.00 | 182 | 25.47 | 351 | 24.50 |
| (Kg/m2) | - | (20.8-25.8) | - | (23.3-27.4) | - | (18.2-24.0) | - | (22.6-27.6) | - | (22.9-27.5) | - | (23.0-27.8) |
| Total cholesterol | 91 | 4.68 | 91 | 4.68 | 91 | 4.60 | 90 | 4.78 | 181 | 4.73 | 348 | 4.90 |
| (mmol/L) | - | (3.93-5.45) | - | (4.03-5.50) | - | (3.82-5.37) | - | (4.03-5.58) | - | (4.03-5.53) | - | (4.30-5.40) |
| LDL | 90 | 2.86 | 91 | 2.93 | 90 | 2.63 | 90 | 2.73 | 181 | 2.83 | 345 | 2.90 |
| (mmol/L) | - | (2.25-3.57) | - | (2.19-3.62) | - | (2.06-3.32) | - | (2.18-3.70) | - | (2.19-3.62) | - | (2.40-3.50) |
| HDL | 91 | 1.09 | 91 | 1.14 | 91 | 1.21 | 90 | 1.21 | 181 | 1.19 | 348 | 1.40 |
| (mmol/L) | - | (0.96-1.29) | - | (0.56-1.37) | - | (1.03-1.47) | - | (1.03-1.40) | - | (0.98-1.40) | - | (1.19-1.65) |
| Triglycerides | 91 | 1.36 | 91 | 1.41 | 91 | 1.32 | 90 | 1.57 | 181 | 1.46 | 348 | 0.93 |
| (mmol/L) | - | (1.07-1.92) | - | (1.06-2.04) | - | (0.92-1.90) | - | (1.22-2.14) | - | (1.13-2.05) | - | (0.68-1.25) |