Table 1. Proteins significantly upregulated in optic nerve tissue 3 weeks after r-mTBI.
Proteins were ranked according to the level of upregulation. Location and type according to IPA. Symbols as per UniProt nomenclature.
| # | log ratio | % increase | Entrez Gene Name | Symbol | Accession number | In myelin |
|---|---|---|---|---|---|---|
| 1 | 0.082 | 8.50% | heat shock protein 90kDa beta (Grp94), member 1 | HSP90B1 | P08113 | |
| 2 | 0.091 | 9.50% | vimentin | VIM | P20152 | ☑ |
| 3 | 0.106 | 11.20% | peroxiredoxin 1 | PRDX1 | P35700 | ☑ |
| 4 | 0.127 | 13.50% | eukaryotic translation elongation factor 1 alpha 1 | EEF1A1 | P10126 | ☑ |
| 5 | 0.133 | 14.20% | ribosomal protein S6 | RPS6 | P62754 | ☑ |
| 6 | 0.154 | 16.60% | AHNAK nucleoprotein | AHNAK | E9Q616 | |
| 7 | 0.155 | 16.80% | annexin A2 | ANXA2 | P07356 | ☑ |
| 8 | 0.167 | 18.20% | filamin A, alpha | FLNA | B7FAV1 | |
| 9 | 0.17 | 18.50% | asparaginase like 1 | ASRGL1 | Q8C0M9 | ☑ |
| 10 | 0.187 | 20.60% | leucine aminopeptidase 3 | LAP3 | Q9CPY7-2 | ☑ |
| 11 | 0.194 | 21.40% | actin, beta | ACTB | P60710 | ☑ |
| 12 | 0.208 | 23.10% | complement component 4B (Chido blood group) | C4A/C4B | P01029 | |
| 13 | 0.216 | 24.10% | ribosomal protein S3 | RPS3 | P62908 | ☑ |
| 14 | 0.234 | 26.40% | adenosylhomocysteinase-like 1 | AHCYL1 | Q80SW1 | |
| 15 | 0.234 | 26.40% | peptidylprolyl isomerase B (cyclophilin B) | PPIB | P24369 | ☑ |
| 16 | 0.254 | 28.90% | filamin C, gamma | FLNC | Q8VHX6-2 | |
| 17 | 0.257 | 29.30% | quinoid dihydropteridine reductase | QDPR | Q8BVI4 | ☑ |
| 18 | 0.276 | 31.80% | glutamate-ammonia ligase | GLUL | P15105 | ☑ |
| 19 | 0.276 | 31.80% | moesin | MSN | P26041 | ☑ |
| 20 | 0.287 | 33.20% | heat shock 27kDa protein 1 | HSPB1 | D3YZ06 | |
| 21 | 0.293 | 34.00% | histone cluster 1, H2bk | HIST1H2BK | Q8CGP1 | |
| 22 | 0.324 | 38.30% | glucosamine-6-phosphate deaminase 1 | GNPDA1 | O88958 | |
| 23 | 0.342 | 40.80% | apolipoprotein E | APOE | P08226 | ☑ |
| 24 | 0.372 | 45.10% | Protein inferred from homology † | A8DUK4 | ||
| 25 | 0.378 | 45.90% | albumin | ALB | P07724 | ☑ |
| 26 | 0.393 | 48.10% | predicted gene, 17669; Protein predicted | Gm17669 | F6QL70 | |
| 27 | 0.401 | 49.30% | calponin 3, acidic | CNN3 | Q9DAW9 | |
| 28 | 0.45 | 56.80% | myristoylated alanine rich PKC substrate | Markcs | P26645 | ☑ |
| 29 | 0.616 | 85.20% | cathepsin D | CTSD | P18242 | ☑ |
☑—protein detected in mouse myelin [17];
†—protein not identified in the IPA database; according to UniProt (The UniProt Consortium; http://www.uniprot.org/), it represents a beta-globin, an iron-binding protein typically a part of the hemoglobin molecule.