Table 2. Proteins significantly downregulated in optic nerve tissue 3 weeks after r-mTBI.
Proteins were ranked according to the level of downregulation. Location and type according to IPA. Symbols as per UniProt nomenclature.
| # | log ratio | % decrease | Entrez Gene Name | Symbol | Accession number | in myelin |
|---|---|---|---|---|---|---|
| 1 | -0.096 | -9.2% | spectrin, alpha, non-erythrocytic 1 | SPTAN1 | P16546 | ☑ |
| 2 | -0.107 | -10.1% | dihydropyrimidinase-like 2 | DPYSL2 | O08553 | ☑ |
| 3 | -0.109 | -10.3% | spectrin, beta, non-erythrocytic 1 | SPTBN1 | Q62261 | ☑ |
| 4 | -0.14 | -13.1% | spectrin, alpha, non-erythrocytic 1 | SPTAN1 | A3KGU5 | |
| 5 | -0.149 | -13.8% | myelin basic protein | MBP | P04370-9 | ☑ |
| 6 | -0.191 | -17.4% | tubulin, beta 2A class IIa | TUBB2A | Q7TMM9 | ☑ |
| 7 | -0.197 | -17.9% | heat shock 70kDa protein 12A | HSPA12A | Q8K0U4 | ☑ |
| 8 | -0.21 | -18.9% | collagen, type VI, alpha 3 | COL6A3 | E9PWQ3 | |
| 9 | -0.223 | -20.0% | collapsin response mediator protein 1 | CRMP1 | P97427 | ☑ |
| 10 | -0.225 | -20.1% | microtubule-associated protein 1A | MAP1A | A2ARP8 | |
| 11 | -0.228 | -20.4% | collagen, type VI, alpha 1 | COL6A1 | Q04857 | |
| 12 | -0.237 | -21.1% | erythrocyte membrane protein band 4.1-like 3 | EPB41L3 | Q9WV92-7 | ☑ |
| 13 | -0.251 | -22.2% | collagen, type VI, alpha 3 | COL6A3 | J3QQ16 | |
| 14 | -0.255 | -22.5% | myelin associated glycoprotein | MAG | P20917-2 | ☑ |
| 15 | -0.259 | -22.8% | ATPase, Na+/K+ transporting, alpha 3 polypeptide | ATP1A3 | Q6PIC6 | ☑ |
| 16 | -0.26 | -22.9% | dihydropyrimidinase-like 5 | DPYSL5 | Q9EQF6 | ☑ |
| 17 | -0.268 | -23.5% | 2',3'-cyclic nucleotide 3' phosphodiesterase | CNP | P16330 | ☑ |
| 18 | -0.275 | -24.0% | peripherin | PRPH | P15331-3 | |
| 19 | -0.305 | -26.3% | calbindin 2 | CALB2 | Q08331 | ☑ |
| 20 | -0.33 | -28.1% | neurofilament, heavy polypeptide | NEFH | P19246 | ☑ |
| 21 | -0.399 | -32.9% | internexin neuronal intermediate filament protein | INA | P46660 | ☑ |
| 22 | -0.4 | -33.0% | A kinase (PRKA) anchor protein 12 | AKAP12 | Q9WTQ5-2 | ☑ |
| 23 | -0.417 | -34.1% | synuclein, gamma | SNCG | Q9Z0F7 | |
| 24 | -0.426 | -34.7% | neurofilament, medium polypeptide | Nefm | P08553 | ☑ |
| 25 | -0.436 | -35.3% | microtubule-associated protein 1B | MAP1B | P14873 | ☑ |
| 26 | -0.496 | -39.1% | tubulin, alpha 4a | TUBA4A | P68368 | ☑ |
| 27 | -0.506 | -39.7% | neurofilament, light polypeptide | NEFL | P08551 | ☑ |
| 28 | -0.626 | -46.5% | AHNAK nucleoprotein 2 | AHNAK2 | E9PYB0 |
☑—protein detected in mouse myelin [17]