Table 1.

Study Design

Cohort	Dosing Schedule	No. of patients
0	20 mg/m2 on days 1 and 2 and 27 mg/m2 on days 8, 9, 15 and 16 of every cycle. Cycles were repeated every 28 days	5
1	20 mg/m2 on days 1 and 2 and 36 mg/m2 on days 8, 9, 15 and 16 of every cycle. Cycles were repeated every 28 days	4
2	20 mg/m2 on days 1 and 2 and 45 mg/m2 on days 8, 9, 15 and 16 of every cycle. Cycles were repeated every 28 day	4
3	20 mg/m2 on days 1 and 2 and 56 mg/m2 on days 8, 9, 15 and 16 of every cycle. Cycles were repeated every 28 days	6