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Plausible biosynthetic pathway leading to atisine in A. heterophyllum. The metabolic network has been constructed by including glycolysis, phosphorylated, glycerate, glycolate, MVA/MEP and diterpene biosynthetic pathways. Question marks indicate missing enzymes with no available information. Green color represents the positions of enzymes identified as candidate genes in atisine biosynthesis. Abbreviations are elaborated in supplementary Table 4
