Table 3.
Differentially expressed proteins associated with cell growth and division, capsule synthesis, and virulence.
| Protein name | Locus | Functions | Ratio(ΔgidA/SC-19) | Peptides | Sequence coverage (%) |
|---|---|---|---|---|---|
| CELL GROWTH AND DIVISION | |||||
| Cps2C | SSU05_0566 | Tyrosine-protein kinase Wze | 0.4555 | 1 | 28.57 |
| DivIVA | SSU05_0487 | Cell division initiation protein | 0.8229 | 1 | 59.83 |
| – | SSU05_0133 | Adenine-specific DNA methylase | 0.8010 | 8 | 34.70 |
| FtsI | SSU05_1354 | Cell division protein | 0.8185 | 5 | 31.84 |
| FtsQ | SSU05_0478 | Cell division septal protein | 0.8223 | 8 | 28.33 |
| FtsX | SSU05_1410 | Cell division protein | 1.2542 | 6 | 24.60 |
| GpsB | SSU05_0417 | Cell division protein | 1.3016 | 6 | 62.16 |
| GyrA | SSU05_1267 | DNA gyrase subunit A | 0.8140 | 9 | 16.43 |
| GyrB | SSU05_1510 | DNA gyrase subunit B | 0.7152 | 2 | 45.38 |
| MurD | SSU05_0476 | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase | 0.7718 | 14 | 39.87 |
| PcrA | SSU05_0731 | Superfamily I DNA/RNA helicase | 0.8044 | 15 | 20.42 |
| PhpP | SSU05_0427 | Serine/threonine protein phosphatase | 0.8067 | 11 | 59.59 |
| RecN | SSU05_1651 | DNA repair ATPase | 0.8321 | 14 | 35.99 |
| RmuC | SSU05_1991 | DNA recombination protein | 0.7751 | 8 | 19.90 |
| RnhB | SSU05_0996 | Ribonuclease HII | 0.8074 | 8 | 35.41 |
| RnmV | SSU05_2010 | DNA primase | 0.7144 | 6 | 26.53 |
| RNase H | SSU05_0226 | Ribonuclease HIII | 0.7297 | 4 | 14.86 |
| StkP | SSU05_0428 | Serine/threonine protein kinase | 0.8129 | 5 | 32.53 |
| Tag | SSU05_0061 | 3-methyladenine DNA glycosylase | 0.7738 | 1 | 10.58 |
| – | SSU05_0872 | Chromosome segregation ATPase | 0.7753 | 13 | 25.46 |
| XerS | SSU05_0881 | Site-specific tyrosine recombinase | 0.6361 | 1 | 5.90 |
| XerD | SSU05_1702 | Site-specific tyrosine recombinase XerD-like protein | 0.5529 | 3 | 15.64 |
| – | SSU05_1815 | Ribonucleases G and E | 0.6327 | 6 | 6.42 |
| CAPSULE SYNTHESIS | |||||
| Cps2C | SSU05_0566 | Tyrosine-protein kinase Wze | 0.4555 | 1 | 28.57 |
| Cps2F | SSU05_0569 | Rhamnosyltransferase | 1.5931 | 1 | 10.28 |
| Cps2P | SSU05_0578 | Sialic acid synthase | 1.4255 | 6 | 76.63 |
| Cps2Q | SSU05_0579 | UNP-N-acetyglucosamine 2-epimerase | 1.2001 | 17 | 53.58 |
| Cps2R | SSU05_0580 | Acetyltransferase | 1.2131 | 2 | 44.23 |
| Cps2S | SSU05_0581 | CMP-N-acetylneuraminic acid synthetase | 1.2388 | 2 | 59.47 |
| VIRULENCE-ASSOCIATED PROTEINS | |||||
| ArcA | SSU05_0624 | Arginine deiminase | 0.4071 | 15 | 43.77 |
| ArcB | SSU05_0626 | Ornithine carbamoyltransferase | 0.4561 | 10 | 35.91 |
| ArcC | SSU05_0627 | Carbamate kinase | 0.3703 | 4 | 23.17 |
| DltA | SSU05_0638 | D-alanine-poly(phosphoribitol) ligase subunit 1 | 0.8186 | 11 | 25.24 |
| Enolase | SSU05_1503 | Phosphopyruvate hydratase | 0.8146 | 26 | 72.64 |
| GAPDH | SSU05_0155 | Glyceraldehyde-3-phosphate dehydrogenase | 0.7700 | 3 | 90.77 |
| GlnA | SSU05_0160 | Glutamine synthetase | 0.8024 | 15 | 48.21 |
| GtfA | SSU05_1555 | Glycosidase | 0.6384 | 2 | 6.22 |
| IMPDH | SSU05_2183 | Inosine 5′-monophosphate dehydrogenase | 0.6649 | 1 | 45.60 |
| PurA | SSU05_1966 | Adenylosuccinate synthase | 0.7722 | 22 | 60.23 |
| SadP | SSU05_0272 | Translation initiation factor 2 GTPase | 0.6302 | 9 | 18.43 |
| Sly | SSU05_1403 | Suilysin | 0.6552 | 4 | 11.26 |