Table 1.
The pivotal edges of the human brain WM network and their properties.
| No. | Region A | Region B | Normalized EBC | Fiber Length (mm) | Class | Lobes | WM tracts | Connection category | Vulnerability (%) |
|---|---|---|---|---|---|---|---|---|---|
| 1 | PoCG.R | PCu.L | 5.33 | 114.84 | InterHemi | LP-RP | CC | Feeder | 0.333 |
| 2 | PCu.L | STG.L | 5.26 | 87.92 | InterLobe | LP-LT | Short tract | Feeder | 0.242 |
| 3 | PCu.L | PUT.L | 4.93 | 88.92 | InterLobe | LP-LS | Projection tract | Rich-club | 0.212 |
| 4 | ORBsup.L | ORBsup.R | 4.79 | 86.84 | InterHemi | LF-RF | CC | Rich-club | 0.287 |
| 5 | PCu.R | STG.R | 3.75 | 87.45 | InterLobe | RP-RT | Short tract | Feeder | 0.248 |
| 6 | PCu.R | PUT.R | 3.73 | 81.81 | InterLobe | RP-RS | Projection tract | Rich-club | 0.250 |
| 7 | HIP.L | HIP.R | 3.53 | 92.38 | InterHemi | LT-RT | CC | Local | 0.395 |
| 8 | SFGdor.R | IFGtriang.L | 3.36 | 98.42 | InterHemi | LF-RF | CC | Feeder | 0.220 |
| 9 | HES.L | STG.L | 3.29 | 18.61 | IntraLobe | LT-LT | Short tract | Local | 1.505 |
| 10 | HES.R | STG.R | 3.29 | 14.82 | IntraLobe | RT-RT | Short tract | Local | 1.456 |
| 11 | SPG.L | SPG.R | 3.17 | 114.43 | InterHemi | LP-RP | CC | Local | 0.153 |
| 12 | SPG.R | PCu.L | 2.92 | 111.02 | InterHemi | LP-RP | CC | Feeder | 0.102 |
| 13 | ORBsup.R | ITG.R | 2.72 | 76.77 | InterLobe | RF-RT | UF | Feeder | 0.240 |
| 14 | SOG.R | MOG.L | 2.62 | 137.84 | InterHemi | LR-RO | CC | Rich-club | 0.162 |
| 15 | CAL.R | PCu.L | 2.53 | 68.02 | InterHemi | LP-RO | CC | Rich-club | 0.156 |
| 16 | SPG.L | PCu.R | 2.42 | 105.99 | InterHemi | LP-RP | CC | Feeder | 0.139 |
| 17 | PCu.L | MTG.L | 2.35 | 90.80 | InterLobe | LP-LT | Cingulum | Feeder | 0.111 |
| 18 | PHG.L | PCu.L | 2.25 | 39.17 | InterLobe | LP-LT | Cingulum | Feeder | 0.199 |
| 19 | SFGdor.R | ORBsup.R | 2.14 | 13.82 | IntraLobe | RF-RF | Short tract | Rich-club | 0.149 |
| 20 | ACG.L | PCu.L | 2.03 | 75.95 | InterLobe | LF-LP | Cingulum | Feeder | 0.218 |
| 21 | MOG.L | PUT.L | 1.84 | 89.45 | IntraLobe | LO-LS | IFO | Rich-club | 0.107 |
| 22 | SFGdor.L | SFGdor.R | 1.78 | 89.09 | InterHemi | LF-RF | CC | Feeder | 0.065 |
| 23 | ORBsup.R | TPOmid.R | 1.78 | 70.34 | InterLobe | RF-RT | UF | Feeder | 0.111 |
| 24 | PCu.L | PCL.L | 1.70 | 13.62 | IntraLobe | LP-LP | Short tract | Feeder | 0.172 |
| 25 | HIP.R | THA.R | 1.70 | 40.31 | InterLobe | RT-RS | Undefined | Local | 0.196 |
| 26 | CAL.L | PCu.R | 1.67 | 63.70 | InterHemi | RP-LO | CC | Rich-club | 0.143 |
| 27 | PreCG.R | PCL.L | 1.65 | 125.33 | InterHemi | RF-LP | CC | Local | 0.142 |
| 28 | PCu.L | THA.L | 1.63 | 70.58 | InterLobe | LP-LS | Projection tract | Feeder | 0.102 |
| 29 | DCG.L | PCu.L | 1.60 | 33.52 | InterLobe | LF-LP | Cingulum | Feeder | 0.176 |
| 30 | ORBsup.R | PUT.R | 1.59 | 38.59 | InterLobe | RF-RS | Projection tract | Rich-club | 0.097 |
| 31 | PHG.R | PCu.R | 1.57 | 40.99 | InterLobe | RP-RT | Cingulum | Feeder | 0.121 |
| 32 | DCG.R | PCu.R | 1.55 | 32.99 | InterLobe | RF-RP | Cingulum | Feeder | 0.190 |
| 33 | ORBsup.L | ITG.L | 1.54 | 70.46 | InterLobe | LF-LT | UF | Feeder | 0.149 |
| 34 | PCu.L | PCu.R | 1.53 | 96.65 | InterHemi | LP-RP | CC | Rich-club | 0.056 |
| 35 | ACG.R | PCu.R | 1.48 | 84.79 | InterLobe | RF-RP | Cingulum | Feeder | 0.181 |
| 36 | CAU.L | PUT.L | 1.42 | 11.21 | IntraLobe | LS-LS | Undefined | Feeder | 0.116 |
| 37 | SOG.R | PCu.L | 1.40 | 93.38 | InterHemi | LP-RO | CC | Rich-club | 0.079 |
| 38 | ORBinf.L | MOG.L | 1.38 | 137.25 | InterLobe | LF-RO | IFO | Feeder | 0.158 |
| 39 | PUT.R | PAL.R | 1.34 | 12.63 | IntraLobe | RS-RS | Undefined | Feeder | 0.133 |
| 40 | PCu.L | PCL.R | 1.30 | 111.80 | InterHemi | LP-RP | CC | Feeder | 0.218 |
| 41 | SFGdor.R | PUT.R | 1.28 | 48.90 | InterLobe | RF-RS | Projection tract | Rich-club | 0.074 |
| 42 | PCG.R | PCu.L | 1.20 | 33.89 | InterHemi | LP-RP | CC | Feeder | 0.162 |
| 43 | ORBinf.R | CAL.R | 1.17 | 144.23 | InterLobe | RF-RO | IFO | Feeder | 0.123 |
| 44 | ORBsup.L | INS.L | 1.12 | 18.42 | InterLobe | LF-LS | UF | Feeder | 0.134 |
| 45 | PreCG.R | MTG.R | 1.11 | 95.09 | InterLobe | RF-RT | Short tract | Local | 0.128 |
| 46 | CAU.L | THA.L | 1.07 | 25.22 | IntraLobe | LS-LS | Undefined | Local | 0.116 |
| 47 | PUT.L | PAL.L | 1.06 | 12.18 | IntraLobe | LS-LS | Undefined | Feeder | 0.102 |
| 48 | CAU.R | PUT.R | 1.04 | 11.82 | IntraLobe | RS-RS | Undefined | Feeder | 0.097 |
Fiber tracts were determined by examining the tractography result of each individual with prior anatomical knowledge. No., number; EBC, edge betweenness centrality; PoCG, postcentral gyrus; R, right; PCu, precuneus; L, left; ORBsup, superior frontal gyrus, orbital part; HIP, hippocampus; SFGdor, superior frontal gyrus, dorsolateral; HES, Heschl gyrus; SPG, superior parietal gyrus; SOG, superior occipital gyrus; CAL, calcarine fissure and surrounding cortex; PHG, parahippocampal gyrus; ACG, anterior cingulate and paracingulate gyri; PreCG, precentral gyrus; DCG, median cingulate and paracingulate gyri; CAU, caudate nucleus; ORBinf, inferior frontal gyrus, orbital part; PCG, posterior cingulate gyrus; PUT, putamen; STG, superior temporal gyrus; IFGtriang, inferior frontal gyrus, triangular part; ITG, inferior temporal gyrus; MOG, middle occipital gyrus; MTG, middle temporal gyrus; TPOmid, temporal pole: middle temporal gyrus; PCL, paracentral lobule; THA, thalamus; INS, insula; InterHemi, inter-hemispheric connection; InterLobe; intra-hemispheric inter-lobe connection; IntraLobe, within lobe connections; LP, left parietal lobe; RP, right parietal lobe; LT, left temporal lobe; LS, left subcortical; LF, left frontal lobe; RF, right frontal lobe; RT, right temporal lobe; RS, right subcortical; RO, right occipital; LO, left occipital; CC, corpus callosum; UF, uncinate fasciculus; IFO, inferior frontooccipital fasciculus.