Table 3.

Organ distribution of radioactivity after intravenous injection of [¹¹C]CB184 and ^[11C]CB190 into mice

Organ	Time after injection (min)
	1	5	15	30	60
[11C]CB184 uptake (%ID/g)
Blood	5.14 ± 0.33	3.41 ± 0.56	1.51 ± 0.23	0.96 ± 0.26	0.64 ± 0.08
Heart	13.23 ± 1.44	12.34 ± 2.52	13.18 ± 5.51	13.83 ± 2.08	7.72 ± 1.69
Lung	94.82 ± 33.08	54.35 ± 15.27	25.30 ± 14.71	33.19 ± 18.49	13.82 ± 2.33
Liver	2.06 ± 3.31	9.81 ± 4.52	11.15 ± 7.75	2.69 ± 0.94	6.66 ± 1.75
Pancreas	3.66 ± 0.88	4.28 ± 1.40	5.49 ± 0.98	3.00 ± 0.87	3.57 ± 0.82
Spleen	4.12 ± 1.80	19.58 ± 6.59	13.78 ± 0.89	6.51 ± 2.13	10.08 ± 0.50
Kidney	9.04 ± 1.67	13.06 ± 2.68	42.55 ± 32.24	10.99 ± 1.93	11.69 ± 2.56
Intestine	4.47 ± 0.88	6.33 ± 2.91	3.58 ± 1.89	8.07 ± 4.84	5.08 ± 1.87
Testis	0.63 ± 0.41	1.10 ± 0.61	0.70 ± 0.30	0.58 ± 0.17	0.73 ± 0.09
[11C]CB190 uptake (%ID/g)
Blood	3.73 ± 0.83	2.42 ± 1.20	1.03 ± 0.22	0.70 ± 0.0.13	0.59 ± 0.10
Heart	15.03 ± 2.17	14.45 ± 1.85	11.74 ± 1.78	9.84 ± 1.84	10.55 ± 7.26
Lung	84.23 ± 28.14	42.18 ± 15.34	27.61 ± 6.57	19.39 ± 3.16	51.52 ± 29.19
Liver	2.65 ± 0.58	3.04 ± 0.31	5.46 ± 1.17	5.10 ± 0.77	2.09 ± 1.32
Pancreas	4.08 ± 1.23	4.40 ± 0.57	5.15 ± 0.46	4.78 ± 1.29	3.24 ± 1.74
Spleen	3.95 ± 1.39	7.59 ± 1.85	11.05 ± 2.47	11.64 ± 1.49	4.31 ± 3.12
Kidney	10.60 ± 3.43	12.92 ± 2.46	17.51 ± 0.56	15.04 ± 2.77	8.98 ± 4.94
Intestine	4.43 ± 0.55	5.47 ± 1.10	4.93 ± 1.64	3.87 ± 2.11	3.48 ± 2.59
Testis	0.86 ± 0.55	0.95 ± 0.20	1.06 ± 0.27	0.94 ± 0.15	0.62 ± 0.46

Data represent mean ± SD of four animals