Table 4.

Regional brain distribution of [¹¹C]CB184, [¹¹C]CB190 and [¹¹C](R)-PK11195 in mice after treatment with unlabeled drugs

Region	Injected drug
	Control	PK11195	Flumazenil
[11C]CB184 uptake (%ID/g)
Olfactory bulb	1.45 ± 0.03	0.92 ± 0.11*	1.36 ± 0.30
Cortex	0.986 ± 0.073	0.594 ± 0.037*	0.965 ± 0.075
Striatum	0.864 ± 0.135	0.616 ± 0.026	0.806 ± 0.141
Hippocampus	1.225 ± 0.067	0.659 ± 0.099*	1.087 ± 0.122
Thalamus	0.985 ± 0.042	0.625 ± 0.024*	0.908 ± 0.159
Midbrain	0.965 ± 0.071	0.626 ± 0.031*	0.994 ± 0.228
Cerebellum	1.384 ± 0.091	0.729 ± 0.057*	1.361 ± 0.185
Pons	1.045 ± 0.102	0.655 ± 0.045*	1.003 ± 0.180
[11C]CB190 uptake (%ID/g)
Olfactory bulb	1.434 ± 0.090	1.026 ± 0.277*	1.329 ± 0.183
Cortex	0.838 ± 0.072	0.731 ± 0.227	0.722 ± 0.080
Striatum	0.715 ± 0.052	0.738 ± 0.235	0.704 ± 0.115
Hippocampus	0.887 ± 0.171	0.763 ± 0.134	0.643 ± 0.083
Thalamus	0.761 ± 0.084	0.702 ± 0.220	0.718 ± 0.097
Midbrain	0.950 ± 0.062	0.781 ± 0.214	0.830 ± 0.313
Cerebellum	1.363 ± 0.046	0.849 ± 0.232*	1.223 ± 0.275
Pons	0.890 ± 0.076	0.682 ± 0.199	0.793 ± 0.122
[11C](R)-PK11195 uptake (%ID/g)
Olfactory bulb	1.129 ± 0.107	0.481 ± 0.240*	1.015 ± 0.218
Cortex	0.626 ± 0.191	0.409 ± 0.112	0.606 ± 0.048
Striatum	0.507 ± 0.090	0.308 ± 0.089	0.634 ± 0.205
Hippocampus	0.730 ± 0.225	0.390 ± 0.054	0.746 ± 0.248
Thalamus	0.578 ± 0.297	0.431 ± 0.205	0.456 ± 0.068
Midbrain	0.610 ± 0.056	0.359 ± 0.052*	0.648 ± 0.134
Cerebellum	1.230 ± 0.243	0.389 ± 0.025*	1.171 ± 0.222
Pons	1.129 ± 0.107	0.481 ± 0.240	1.015 ± 0.218

Data represent mean ± SD of four animals. Blocking drugs were intravenously injected 1 min prior to the tracer administration. Data were analyzed 1-way ANOVA with Bonferroni’s correction. Differences were considered significant at a p value less than 0.0167 (*)